Amlodipine (besylate), CAS 111470-99-6

Formulation: A solid

Formal Name: 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid, 3-ethyl 5-methyl ester, monobenzenesulfonate

Purity: ≥98%

Formula Markup: C20H25ClN2O5 • C6H6O3S

Formula Weight: 567,1

Shelf life (days): 1460

CAS Number: 111470-99-6

Notes: Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle.{23674} Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues. Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition in vitro and in vivo.{23673} Formulations containing amlodipine have been used in the treatment of hypertension.

• Artikelnummer: CAY14886-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 14886-25
• Green Labware: Nein
• Verpackungseinheit: 25 g
• Mengeneinheit: STK
• Methode: Reinstoffe