Amlodipine-d4 (maleate), CAS 1185246-15-4

Formulation: A solid

Formal Name: 2-[(2-aminoethoxy-1,1,2,2-d4)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid, 3-ethyl 5-methyl ester, 2-butenedioate

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C20H21ClD4N2O5 • C4H4O4

Formula Weight: 529

Shelf life (days): 1460

CAS Number: 1185246-15-4

Notes: Amlodipine-d4 is intended for use as an internal standard for the quantification of amlodipine (Item No. 14838) by GC- or LC-MS. Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle.{23674} Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues.{23674} Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition in vitro and in vivo.{23673} Formulations containing amlodipine have been used in the treatment of hypertension.

• Artikelnummer: CAY25035-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25035-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung