AMTB, CAS 926023-82-7

Formulation: A solid

Formal Name: N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)-benzamide, monohydrochloride

Purity: ≥98%

Formula Markup: C23H26N2O2S • HCl

Formula Weight: 431

Shelf life (days): 1460

CAS Number: 926023-82-7

Notes: AMTB is an antagonist of transient receptor potential melastatin 8 (TRPM8).{37683} It inhibits calcium influx induced by the TRPM8 agonist icilin (Item No. 10137) with an IC50 value of 0.58 µM. AMTB (3 mg/kg) decreases the number of volume-induced bladder contractions in a rat model of noxious bladder distension. It also decreases the visceromotor reflex response to urinary bladder distension (ID50 = 2.42 mg/kg), indicating antinociceptive activity. AMTB inhibits the sodium channel (Nav) isoforms Nav1.1-1.8 (IC50s = 2-14.8 µM) and decreases viability of MDA-MB-231 and SK-BR-3 breast cancer cells (IC50s = ~23.7 and 17.3 µM, respectively) in a TRPM8-independent manner.{37684}

• Artikelnummer: CAY25336-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25336-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK