Amylin (rat, mouse) (trifluoroacetate salt)

Formulation: A lyophilized powder

Formal Name: L-lysyl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-valyl-L-arginyl-L-seryl-L-seryl-L-asparaginyl-L-asparaginyl-L-leucylglycyl-L-prolyl-L-valyl-L-leucyl-L-prolyl-L-prolyl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-asparaginyl-L-threonyl-L-tyrosinamide, cyclic (2→7)-disulfide, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C167H272N52O53S2 • XCF3COOH

Formula Weight: 3920,4

Shelf life (days): 1460

Notes: Amylin is a 37-residue peptide hormone secreted by pancreatic β-cells that reduces food intake, modifies glycogen synthesis, slows gastric emptying, and increases satiety.{35231,38842,38841,38840} It binds to heteromeric complexes of human calcitonin receptor 2 (CTR2) with receptor activity-modifying protein (RAMP) 1 or 3 (IC50s = 7.86 and 6.35 nM, respectively).{39432} It also binds to mouse α-thyroid-stimulating hormone thyrotroph (α-TSH) cells (IC50 = 10.5 nM) and rat nucleus accumbens membrane preparations (Ki = 0.024 nM).{38840,39432} In vitro, amylin (100 nM) inhibits insulin-induced, but not basal, glycogen synthesis in hepatocytes isolated from fasted rats.{38841} It also inhibits insulin-induced glycogen synthesis ex vivo in isolated soleus muscle from fasted rats.{38840} In vivo, amylin delays gastric emptying in rats (ED50 = 69 pmol) and decreases food intake in fasted mice (ED50 = 110 μg/kg).{38842,38840} Unlike human amylin (Item No. 24274), rat amylin does not form fibrils and is not cytotoxic.{38843}

• Artikelnummer: CAY24275
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24275-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK