Anamorelin, CAS 249921-19-5

Formulation: A crystalline solid

Formal Name: (3R)-1-[(2R)-2-[(2-amino-2-methyl-1-oxopropyl)amino]-3-(1H-indol-3-yl)-1-oxopropyl]-3-(phenylmethyl)-1,2,2-trimethylhydrazide, 3-piperidinecarboxylic acid

Purity: ≥98%

Formula Markup: C31H42N6O3

Formula Weight: 546,7

Shelf life (days): 1460

CAS Number: 249921-19-5

Notes: Anamorelin is a small molecule agonist of the growth hormone (GH) secretagogue receptor 1a (GHS-R1a) and a mimetic of ghrelin (Item Nos. 15072 / 24458; Ki = 0.7 nM).{41766,41767} It induces calcium mobilization in CHO cells expressing rat GHS-R1a in a concentration-dependent manner and GH release from rat pituitary cells (EC50 = 1.5 nM). In vivo, anamorelin stimulates GH release in sham and vagotomized rats in a dose-dependent manner.{41766} Anamorelin (3-30 mg/kg) also increases food intake in rats.{41767} Formulations containing anamorelin have been used to treat cancer anorexia and cachexia in patients with non-small cell lung cancer.

• Artikelnummer: CAY24676-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24676-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK