Anethole Trithione, CAS 532-11-6

Formulation: A solid

Formal Name: 5-(4-methoxyphenyl)-3H-1,2-dithiole-3-thione

Purity: ≥98%

Formula Markup: C10H8OS3

Formula Weight: 240,4

Shelf life (days): 1460

CAS Number: 532-11-6

Notes: Anethole trithione is a dithiolthione with diverse biological activities.{69024,69025,69026,69027} It selectively binds to α-adrenergic receptors (α-ARs) over β-ARs and muscarinic acetylcholine receptors (mAChRs) in isolated rat parotid acini (IC50s = 16.7, >100, and >100 µM, respectively).{69024} Anethole trithione enhances saliva secretion induced by the mAChR agonist pilocarpine (Item No. 14487) or electrical stimulation of the parasympathetic nerve in rats.{69025} It reduces tumor incidence and multiplicity in a rat model of azoxymethane-induced colon adenocarcinoma when administered in the diet at 100 and 200 ppm.{69026} Anethole trithione (500 mg/kg) prevents decreases in hepatic glutathione (GSH) levels and decreases mortality in mouse models of hepatotoxicity induced by acetaminophen (Item No. 10024) or carbon tetrachloride.{69027} Formulations containing anethole trithione have been used in the treatment of dry mouth.

• Artikelnummer: CAY35397-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35397-25
• Green Labware: Nein
• Verpackungseinheit: 25 g
• Mengeneinheit: STK
• Methode: Reinstoffe