Formulation: A crystalline solid
Formal Name: 5-L-isoleucine-2-8-angiotensin II
Purity: ≥98%
Formula Markup: C46H66N12O9
Formula Weight: 931,1
Shelf life (days): 1460
CAS Number: 13602-53-4
Notes: Angiotensin III (Ang III) is a heptapeptide agonist at the angiotensin 1 (AT1) and AT2 receptors, with a 30-fold higher affinity for AT2 compared with AT1 in HEK293 cells.{26232,34120} Ang III is the preferred agonist for renal AT2 receptors, which are responsible for sodium excretion into the urine.{34101} Ang III induces the same level of aldosterone synthesis as Ang II but has lower vasoconstrictive activity in vivo.{34099} In the brain renin-angiotensin system, Ang III increases sympathetic nerve activity and vasopressin release and dampens the baroreflex leading to higher blood pressure.{34100}