Antazoline (hydrochloride), CAS 2508-72-7

Formulation: A crystalline solid

Formal Name: 4,5-dihydro-N-phenyl-N-(phenylmethyl)-1H-imidazole-2-methanamine, monohydrochloride

Purity: ≥98%

Formula Markup: C17H19N3 • HCl

Formula Weight: 301,8

Shelf life (days): 1460

CAS Number: 2508-72-7

Notes: Antazoline is a histamine H1 receptor antagonist that binds to histamine H1receptors with a Ki value of 38.4 nM in cell membranes expressing human recombinant H1 receptors.{33247} Antazoline reduces histamine-induced IL-6 and IL-8 production in human conjunctival epithelial cells (IC50s = 1 and 0.652 μM, respectively). It completely prevents anaphylaxis in rabbits sensitized to egg albumin and increases survival in a guinea pig model of histamine-induced bronchospasm.{40285} Antazoline (10-30 µM) eliminates atrial fibrillation induced by acetylcholine and isoproterenol (Item No. 15592) in isolated rabbit hearts by increasing the atrial effective refractory period and interatrial conduction time in a dose-dependent manner.{40286} Antazoline also binds to NMDA receptors (Ki = 13 μM) and reduces glutamate-induced toxicity in cerebellar granule cells (EC50 = 13 μM).{40287}

• Artikelnummer: CAY23415-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23415-500
• Green Labware: Nein
• Verpackungseinheit: 500 mg
• Mengeneinheit: STK