APD597, CAS 897732-93-3

Formulation: A crystalline solid

Formal Name: 4-[[5-methoxy-6-[[2-methyl-6-(methylsulfonyl)-3-pyridinyl]amino]-4-pyrimidinyl]oxy]-1-piperidinecarboxylic acid, 1-methylethyl ester

Purity: ≥98%

Formula Markup: C21H29N5O6S

Formula Weight: 479,6

Shelf life (days): 1460

CAS Number: 897732-93-3

Notes: APD597 is an orally bioavailable agonist of GPR119 that has EC50 values of 46 and 421 nM for the human and rat receptors, respectively, in a homologous time-resolved fluorescence (HTRF) assay.{48588} It increases insulin secretion stimulated by a high, but not low, concentration of glucose in isolated mouse pancreatic β-cells and in isolated human islets.{48589} APD597 (20 mg/kg) increases levels of glucagon-like peptide-1 (GLP-1; Item No. 24460) induced by glucose in mice. It also decreases blood glucose levels in an oral glucose tolerance test in mice when administered at doses of 1 and 10 mg/kg and in Zucker diabetic rats at a dose of 3 mg/kg.{48588}

• Artikelnummer: CAY22950-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22950-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK