Apraclonidine (hydrochloride), CAS 73218-79-8

Formulation: A solid

Formal Name: 2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)-1,4-benzenediamine, monohydrochloride

Purity: ≥98%

Formula Markup: C9H10Cl2N4 • HCl

Formula Weight: 281,6

Shelf life (days): 1460

CAS Number: 73218-79-8

Notes: Apraclonidine is an α2-adrenergic receptor (α2-AR) agonist and structural analog of clonidine (Item No. 15949).{40474} It binds to α2-ARs in calf cortex, rat kidney, and rat spleen with IC50 values of 0.9, 4.3, and 4.2 nM, respectively. Apraclonidine also binds to α2-ARs in rat cerebral cortex, pig submandibular gland and lung tissue, and in dog kidney membrane (Kds = 0.87, 5.28, 1.30, and 5.25 nM, respectively).{40475,40476} It inhibits noradrenaline-stimulated contraction in guinea pig ileum and rabbit vas deferens (EC50s = 7.59 and 6.76 nM, respectively).{40477} Opthalmic formulations containing apraclonidine have been used to treat elevated intraocular pressure.

• Artikelnummer: CAY23904-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23904-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK