ARC 239 (hydrochloride), CAS 55974-42-0

Formulation: A solid

Formal Name: 2-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-4,4-dimethyl-1,3(2H,4H)-isoquinolinedione, dihydrochloride

Purity: ≥98%

Formula Markup: C24H29N3O3 • 2HCl

Formula Weight: 480,4

Shelf life (days): 1460

CAS Number: 55974-42-0

Notes: ARC 239 is an antagonist of α2B-adrenergic receptors (α2B-ARs; Ki = 87.1 nM).{64516,64517,64518} It is selective for α2B-ARs over α2A-ARs (Ki = 3,548 nM) but also inhibits α2C-ARs (Ki = 112.2 nM) and the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 63.1 nM).{64517,64518} ARC 239 also binds to α1A-, α1B-, and α1D-adrenergic receptors (Kds = 0.45, 7.08, and 1.82 nM, respectively) but only induces the release of intracellular calcium in CHO cells expressing the α1B-adrenergic receptors with an EC50 value of 100 µM.{64519} It has commonly been used to determine the selectivity of α2-adrenergic receptor agonists and antagonists.{64520,64521}

• Artikelnummer: CAY36218-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36218-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe