Asapiprant, CAS 932372-01-5

Formulation: A solid

Formal Name: 2-[5-[4-[[4-(1-methylethoxy)phenyl]sulfonyl]-1-piperazinyl]-2-(2-oxazolyl)phenoxy]-acetic acid

Purity: ≥98%

Formula Markup: C24H27N3O7S

Formula Weight: 501,6

Shelf life (days): 1460

CAS Number: 932372-01-5

Notes: Asapiprant is an antagonist of the prostaglandin D1 (PGD1) receptor (DP1; Ki = 0.44 nM).{50862} It is selective for DP1 over DP2, as well as the thromboxane A2 (TXA2), prostaglandin I2 (PGI2), and prostaglandin E1-4 (PGE1-4) receptors (Kis = >5,000, >4,800, >6,300, and 120->6,600 nM, respectively). Asapiprant (1 and 3 mg/kg) reduces PGD2-induced increases in nasal resistance in a guinea model of allergic rhinitis. It reduces nasal secretion, when administered at doses of 3 and 30 mg/kg, and antigen-induced cell infiltration in nasal lavage fluids, when administered at 3 and 10 mg/kg, in a guinea pig model of allergic rhinitis induced by ovalbumin. Asapiprant (10 mg/kg) also decreases airway hyperresponsiveness, inflammatory cell infiltration in bronchoalveolar lavage fluid (BALF), and mucin production in a rat model of ovalbumin-induced asthma.

• Artikelnummer: CAY30008-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30008-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK