Asimadoline, CAS 153205-46-0

Formulation: A crystalline solid

Formal Name: N-[(1S)-2-[(3S)-3-hydroxy-1-pyrrolidinyl]-1-phenylethyl]-N-methyl-α-phenyl-benzeneacetamide

Purity: ≥98%

Formula Markup: C27H30N2O2

Formula Weight: 414,5

Shelf life (days): 1460

CAS Number: 153205-46-0

Notes: Asimadoline is a potent κ-opioid receptor (KOR) agonist (IC50s = 5.6 and 1.2 nM for guinea pig and human receptors, respectively).{47150} It is 501- and 498-fold selective for κ-opioid over μ- and δ-opioid receptors, respectively. Asimadoline is spasmolytic in isolated rat duodenum (IC50 = 4.2 μM) and inhibits spontaneous contractions of isolated rat uterus (IC50 = 12.7 μM). In vivo, asimadoline reduces joint damage in a rat model of arthritis induced by complete Freund's adjuvant (CFA). Asimadoline (25 mg/kg) also reduces the abdominal withdrawal reflex in a model of visceral pain induced by colonic distension in wild-type, but not KOR-/-, mice.{47151}

• Artikelnummer: CAY26411-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26411-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK