AT-121, CAS 2099681-31-7

Formulation: A solution in chloroform

Formal Name: N-[2-[1,2-dihydro-1'-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4'-piperidin]-2-yl]ethyl]-sulfamide

Purity: ≥95%

Formula Markup: C24H38N4O3S

Formula Weight: 462,6

Shelf life (days): 365

CAS Number: 2099681-31-7

Notes: AT-121 is a dual μ-opioid and nociceptin receptor partial agonist (Kis = 16.49 and 3.67 nM, respectively).{35507} It stimulates [35S]GTPγS binding to cell membranes expressing μ-opioid or nociceptin receptors (EC50s = 19.6 and 34.7 nM, respectively). AT-121 (0.003-0.03 mg/kg) decreases capsaicin-induced thermal allodynia without increasing scratching activity in rhesus monkeys in a dose-dependent manner. It lacks reinforcing effects, a marker of abuse potential, and reduces oxycodone, but not food pellet, reinforcement in a drug self-administration assay in rhesus monkeys when administered at doses ranging from 0.3 to 10 μg/kg per injection. AT-121 (0.01 or 0.03 mg/kg) does not induce hyperalgesia, a marker of tolerance development, in rhesus monkeys.

• Artikelnummer: CAY26150-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26150-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK