Atipamezole (hydrochloride), CAS 104075-48-1

Formulation: A crystalline solid

Formal Name: 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole, monohydrochloride

Purity: ≥98%

Formula Markup: C14H16N2 • HCl

Formula Weight: 248,8

Shelf life (days): 1460

CAS Number: 104075-48-1

Notes: Atipamezole is an antagonist of α2A-adrenergic receptors (α2A-ARs; Ki = 1.86 nM).{25705,25706} It is selective for α2A-ARs over α2B- and α1-ARs (Kis = 1,949.83 and 13,300 nM, respectively), as well as over 40 receptors, ion channels, and transporters (IC50s = 540->10,000 nM). Atipamezole (0.04, 0.08, and 1.2 mg/kg) reverses bradycardia and sedation induced by the α2-AR agonist medetomidine in dogs.{60727} It also prevents hypoalgesia induced by the non-steroidal anti-inflammatory drug (NSAID) ketoprofen in sheep.{60728} Atipamezole (0.3 mg/kg) enhances contralateral circling behavior induced by apomorphine or L-DOPA (Item No. 13248) and prolongs the duration of action of L-DOPA in a rat model of Parkinson’s disease.{25704} Formulations containing atipamezole have been used to reverse the sedative and analgesic effects of dexmedetomidine or medetomidine in dogs. Atipamezole is an imidazole that potently antagonizes the α2-adrenoceptor (Ki = 1.6 nM).{25705,25706} It shows selectivity over the α1-adrenoceptor (Ki = 13,300 nM) and is a poor antagonist at a wide variety of other receptors and channels.{25706} Through its effects at the α2-adrenoceptor, atipamezole reverses the sedative and analgesic effects of α2-adrenoceptor agonists, alters cognitive functions and sexual behavior, and has neuroprotective effects.{25706} It may also potentiate the effects of dopaminergic drugs used in Parkinson’s disease.{25706,25704}

• Artikelnummer: CAY9001181-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9001181-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK