AUT1, CAS 1311136-84-1

Formulation: A crystalline solid

Formal Name: 5R-ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione

Purity: ≥98%

Formula Markup: C18H19N3O4

Formula Weight: 341,4

Shelf life (days): 1460

CAS Number: 1311136-84-1

Notes: AUT1 is a positive modulator of the voltage-gated potassium channel subtypes Kv3.1b, Kv3.2a, and Kv3.3 (EC50s = 4.7, 4.9, and 31.6 µM, respectively, in a patch-clamp assay).{46494} It is selective for Kv3.1b, Kv3.2a, and Kv3.3 over Kv1.5 and Kv7.1/minK channels but also inhibits the serotonin (5-HT) transporter, 5-HT3 receptor, and α1 subunit-containing nicotinic acetylcholine receptor (nAChR) in a panel of 26 ion channels, receptors, and transporters. AUT1 increases tetraethylammonium-induced decreases in the firing frequency and amplitude of action potentials in mouse somatosensory cortex slices when used at concentrations of 1 and 10 µM.

• Artikelnummer: CAY28599-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28599-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK