AVN-492, CAS 1220646-23-0

Formulation: A crystalline solid

Formal Name: N2,N6,N6,5,7-pentamethyl-3-(phenylsulfonyl)-pyrazolo[1,5-a]pyrimidine-2,6-diamine

Purity: ≥98%

Formula Markup: C17H21N5O2S

Formula Weight: 359,4

Shelf life (days): 1460

CAS Number: 1220646-23-0

Notes: AVN-492 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 0.09 nM).{52052} It selectively inhibits the 5-HT6 receptor over the 5-HT2B receptor (IC50s = 0.19 and 268 nM, respectively, in a radioligand binding assay). AVN-492 inhibits increases in cAMP levels induced by 5-HT in HEK293 cells expressing the 5-HT6 receptor (IC50 = 1.5 nM). It increases the time spent in the open arms of the elevated plus maze in rats, indicating anxiolytic activity, when administered at a dose of 0.2 mg/kg. AVN-492 (1 mg/kg) also prevents memory deficits induced by the NMDA receptor antagonist MK-801 in a passive avoidance test.

• Artikelnummer: CAY28079-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28079-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK