AZ 12216052, CAS 1290628-31-7

Formulation: A crystalline solid

Formal Name: 2-[[(4-bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]-acetamide

Purity: ≥98%

Formula Markup: C19H22BrNOS

Formula Weight: 392,4

Shelf life (days): 1460

CAS Number: 1290628-31-7

Notes: AZ 12216052 is a positive allosteric modulator of metabotropic glutamate receptor 8 (mGluR8).{53273} It potentiates glutamate-induced [35S]GTPγS binding in GHEK cells expressing human mGluR8b (EC50 = 1 μM). In a cell-based model of Parkinson’s disease, AZ 12216052 inhibits MPP+-induced decreases in the viability of undifferentiated SH-SY5Y cells when used at concentrations ranging from 0.001 to 1 μM and in retinoic acid-differentiated SH-SY5Y cells at 0.1 and 1 μM.{53274} AZ 12216052 (10 mg/kg) increases the time spent in the open areas of the elevated zero maze and reduces the acoustic startle response in mice, indicating anxiolytic-like activity in response to avoidable and unavoidable anxiogenic stimuli, respectively.{53273}

• Artikelnummer: CAY29460-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29460-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK