Azasetron (hydrochloride), CAS 123040-16-4

Formulation: A crystalline solid

Formal Name: N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-8-carboxamide, monohydrochloride

Purity: ≥98%

Formula Markup: C17H20ClN3O3 • HCl

Formula Weight: 386,3

Shelf life (days): 1460

CAS Number: 123040-16-4

Notes: Azasetron is an orally bioavailable antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 2.9 nM).{47619,47620} It is selective for 5-HT3 over 5-HT1A and 5-HT2 (IC50 = >10 μM for both), as well as dopamine D1 and D2 and α1- and α2-adrenergic receptors (IC50s = >10 μM), but it does bind to histamine H1 receptors (IC50 = 4.4 μM). Azasetron inhibits contractions induced by 5-HT (Item No. 14332) in isolated guinea pig ileum (pA2 = 7.04) and isolated rabbit heart (pA2 = 10.06). It inhibits emesis induced by cisplatin (Item No. 13119) in dogs and induced by doxorubicin (Item No. 15007) combined with cyclophosphamide (Item No. 13849) in ferrets when administered at a dose of 1 mg/kg.{47619}

• Artikelnummer: CAY28383-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28383-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK