AZD 2098, CAS 566203-88-1

Formulation: A crystalline solid

Formal Name: 2,3-dichloro-N-(3-methoxy-2-pyrazinyl)-benzenesulfonamide

Purity: ≥98%

Formula Markup: C11H9Cl2N3O3S

Formula Weight: 334,2

Shelf life (days): 1460

CAS Number: 566203-88-1

Notes: AZD 2098 is a CC chemokine receptor 4 (CCR4) antagonist.{50101} AZD 2098 inhibits CCL22-induced calcium flux in CHO cells expressing human recombinant CCR4 (IC50 = 31.6 nM) and CCL22- and CCL17-mediated Th2 cell chemotaxis (IC50 = 501.2 nM for both). AZD 2098 is selective for CCR4 over CXCR1, CXCR2, CCR1, CCR2b, CCR5, CCR7, and CCR8 up to 10 µM in vitro. Administration of AZD 2098 (0.07-2.5 mg/kg, p.o.) to ovalbumin-sensitized, antigen-challenged rats reduces alveolitis and leukocyte infiltration in the lung in a dose-dependent manner.

• Artikelnummer: CAY27633-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27633-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK