AZD 3514, CAS 1240299-33-5

Formulation: A crystalline solid

Formal Name: 1-[4-[2-[4-[1-[7,8-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]-4-piperidinyl]phenoxy]ethyl]-1-piperazinyl]-ethanone

Purity: ≥98%

Formula Markup: C25H32F3N7O2

Formula Weight: 519,6

Shelf life (days): 1460

CAS Number: 1240299-33-5

Notes: AZD 3514 is a selective androgen receptor downregulator (SARD).{58268} It inhibits AR nuclear translocation in LNCaP human prostate cancer cells with an IC50 value of 1.78 µM. AZD 3514 (10 µM) inhibits dihydrotestosterone-induced proliferation of LNCaP and LAPC4 prostate cancer cells.{58269} It reduces testosterone proprionate-induced increases in seminal vesicle weight in castrated rats. AZD 3514 (50 mg/kg) decreases tumor growth of Dunning R3327H prostate tumor implants in rats.

• Artikelnummer: CAY33222-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33222-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK