AZD 9496, CAS 1639042-08-2

Formulation: A crystalline solid

Formal Name: (2E)-3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]phenyl]-2-propenoic acid

Purity: ≥98%

Formula Markup: C25H25F3N2O2

Formula Weight: 442,5

Shelf life (days): 1460

CAS Number: 1639042-08-2

Notes: AZD 9496 is a potent and selective estrogen receptor downregulator (SERD) with an IC50 value of 0.138 nM for estrogen receptor α (ERα) downregulation.{39174} It is selective for ERα compared to other nuclear hormone receptors with IC50 values of 0.0008, 0.54, 9.2, and 30 μM for ERα, progesterone receptor (PR), glucocorticoid receptor (GR), and androgen receptor (AR), respectively. AZD 9496 decreases ERα activity (IC50 = 0.282 nM), measured via quantification of downstream PR activity, and reduces proliferation of MCF-7 breast cancer cells (IC50 = 0.0398 nM). It also inhibits MCF-7 xenograft growth in mice in a dose-dependent manner.

• Artikelnummer: CAY21805-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21805-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK