AZD 3839, CAS 1227163-84-9

Formulation: A solid

Formal Name: (1S)-1-[2-(difluoromethyl)-4-pyridinyl]-4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-1H-isoindol-3-amine

Purity: ≥98%

Formula Markup: C24H16F3N5

Formula Weight: 431,4

Shelf life (days): 1460

CAS Number: 1227163-84-9

Notes: AZD 3839 is an inhibitor of beta-secretase 1 (BACE1).{48539,48540} It selectively binds to BACE1 over BACE2 (Kis = 26.1 and 372.4 nM, respectively, for the human enzymes).{48539} It also inhibits human ether-a-go-go-related gene (hERG) potassium channels expressed in CHO cells (IC50 = 4.8 μM).{48540} AZD 3839 decreases amyloid-β (Aβ) secretion from mouse Neuro2a neuroblastoma cells and primary neurons (IC50s = 32.2 and 50.9 nM, respectively).{48539} It dose- and time-dependently decreases Aβ levels in the plasma and brain of mice and guinea pigs. AZD 3839 also decreases Aβ in the cerebrospinal fluid (CSF) of cynomolgus monkeys when administered at a dose of 20 μmol/kg.

• Artikelnummer: CAY28388-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28388-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK