Azelastine-13C-d3 (hydrochloride), CAS 2930288-75-6

Formulation: A solid

Formal Name: 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-(methyl-13C-d3)-1H-azepin-4-yl)-1(2H)-phthalazinone, monohydrochloride

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C21[13C]H21ClD3N3O • HCl

Formula Weight: 422,4

Shelf life (days): 1460

CAS Number: 2930288-75-6

Notes: Azelastine-13C-d3 is intended for use as an internal standard for the quantification of azelastine (Item No. 20873) by GC- or LC-MS. Azelastine is a histamine H1 receptor antagonist (Ki = 1.26 nM in bovine cerebral cortex membranes).{57737} It is selective for histamine H1 over histamine H3 receptors (Ki = 158.49 nM), as well as α1A- and α1B-adrenergic receptors (Ki = 50.12 nM for both). Azelastine (0.14 µg/animal) reduces nose rubbing, sneezing, and nasal mucosa expression of IL-4 in a dust mite-induced mouse model of allergic rhinitis.{31026} It also reduces infection by a lentivirus pseudotyped with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein, also known as the surface glycoprotein, in HEK293 cells expressing angiotensin-converting enzyme 2 (ACE2) when used at a concentration of 7 µg/ml.{57738} Formulations containing azelastine have been used in the treatment of seasonal allergic rhinitis and vasomotor rhinitis.

• Artikelnummer: CAY33295-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33295-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung