β-Endorphin (1-26) (human) (trifluoroacetate salt)

Formulation: A lyophilized powder

Purity: ≥95%

Formula Markup: C130H208N32O38S • XCF3COOH

Formula Weight: 2859,3

Shelf life (days): 1460

Notes: β-endorphin (1-26) is a neuropeptide found in rat hippocampus, brain stem, and pituitary.{36567} It is also present in the human hypothalamus, where it comprises approximately 13.1% of total β-endorphin.{36566} β-endorphin (1-26) is an opioid receptor agonist that inhibits potassium-induced norepinephrine (NE) release in rat cortical slices (IC50 = 2.5 nM).{42040} It reverses inhibition of potassium-induced NE release from rat cortical slices induced by the opioid antagonists naloxone (Item No. 15594), CTOP, norbinaltorphimine (nor-BNI), and naltrindole (Item No. 9000705; pA2s = 7.59-8.63). In vivo, β-endorphin (1-26) (10 μg, i.c.v.) induces transient bradycardia in anesthetized rats.{42041} Intracerebroventricular administration of β-endorphin (1-26) increases the latency to tail withdrawal in response to thermal stimulation in mice with a median antinociceptive dose (AD50) of 1.57 μg per animal.{42042}

• Artikelnummer: CAY24956
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24956-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK