β-Endorphin (1-27) (human) (trifluoroacetate salt)

Formulation: A lyophilized powder

Purity: ≥95%

Formula Markup: C139H217N33O40S • XCF3COOH

Formula Weight: 3022,5

Shelf life (days): 1460

Notes: β-Endorphin (1-27) is an endogenous peptide that binds to μ-, δ-, and κ-opioid receptors (Kis = 5.31, 6.17, and 39.82 nM, respectively, in COS-1 cells expressing rat receptors).{41636} It binds to rat and mouse brain membrane preparations (IC50s = 1.1 and 5.7 nM, respectively) and induces chemotaxis of human monocytes in vitro when used at a concentration of 1 nM.{41637,40895,40896} Intracerebroventricular administration of β-endorphin (1-27) increases the latency to tail withdrawal in response to thermal stimulation in mice with a median antinociceptive dose (AD50) of 1,500 pmol per animal.{41637} It inhibits antinociception induced by β-endorphin (Item Nos. 24153 / 24955) in mice in response to thermal stimuli when administered at a dose of 65 pmol per animal. In rats, β-endorphin (1-27) does not affect drug-associated place preference when administered at doses up to 20 μg, i.c.v., but inhibits β-endorphin-induced place preference when administered at a dose of 10 μg per animal.{41638}

• Artikelnummer: CAY24957
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24957-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK