BAN ORL 24 (hydrochloride), CAS 1401463-54-4

Formulation: A solid

Formal Name: 1-(phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl)propyl]-2-pyrrolidinecarboxamide, dihydrochloride

Purity: ≥95%

Formula Markup: C27H35N3O2 • 2HCl

Formula Weight: 506,5

Shelf life (days): 1460

CAS Number: 1401463-54-4

Notes: BAN ORL 24 is an antagonist of the nociceptin (NOP) receptor (Ki = 0.24 nM in a radioligand binding assay using CHO cell membranes expressing the human receptor).{62409} It is selective for NOP receptors over μ-, δ-, and κ-opioid receptors (Kis = 0.19, 0.34, and >1 µM, respectively). BAN ORL 24 reduces NOP-induced GTPγS binding (pA2 = 9.98) and calcium mobilization (KB = 0.93 nM) in CHO cells. It inhibits electrically induced twitches in isolated mouse and rat vas deferens, as well as isolated guinea pig ileum, when used at a concentration of 100 nM. BAN ORL 24 (10 mg/kg) reverses thermal and mechanical antinociceptive activities induced by the dual agonist of µ-opioid and NOP receptors BPR1M97 in mice.{62410}

• Artikelnummer: CAY29485-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29485-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK