Formulation: A crystalline solid
Formal Name: (3α,5β,6α,7α)-6-ethyl-24-norcholane-3,7,23-triol
Purity: ≥95%
Formula Markup: C25H44O3
Formula Weight: 392,6
Shelf life (days): 1460
CAS Number: 1612191-86-2
Notes: BAR502 is a dual agonist of the G protein-coupled bile acid-activated receptor and farnesoid x receptor (GP-BAR1 and FXR; EC50s = 0.2 and 1 μM, respectively).{38107} It increases the expression of the FXR-regulated bile salt export pump (BSEP), organic solute transporter α (OSTα), and small heterodimer partner (SHP) in primary hepatocytes isolated from FXR wild-type mice. BAR502 also increases cAMP-luciferase reporter gene expression, a marker of GP-BAR1 activity, in HEK293T cells.