Beclomethasone 17-Propionate, CAS 5534-18-9

Formulation: A solid

Formal Name: (11β,16β)-9-chloro-11,21-dihydroxy-16-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione

Purity: ≥95%

Formula Markup: C25H33ClO6

Formula Weight: 465

Shelf life (days): 1460

CAS Number: 5534-18-9

Notes: Beclomethasone 17-propionate is a glucocorticoid receptor agonist and an active metabolite of the glucocorticoid prodrug beclomethasone dipropionate (Item No. 38880).{68477,68478} It is formed from beclomethasone dipropionate via esterases and is subsequently hydrolyzed to beclomethasone (Item No. 33196).{68478} Beclomethasone 17-propionate binds to the glucocorticoid receptor (IC50 = 3 nM) and inhibits glucocorticoid receptor transrepression induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014), as well as induces transactivation of the glucocorticoid receptor, in CV-1 cells expressing the human receptor in a concentration-dependent manner.{68477} It inhibits LPS-induced increases in IL-6, IL-8, and TNF-α levels in primary human lung macrophages from patients with chronic obstructive pulmonary disease (COPD; IC50s = 0.36, 2.04, and 0.21 nM, respectively).{68479}

• Artikelnummer: CAY38884-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38884-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK