Benztropine-13C-d3 (mesylate)

Formulation: A solid

Formal Name: (1R,3r,5S)-3-(benzhydryloxy)-8-(methyl-13C-d3)-8-azabicyclo[3.2.1]octane

Purity: ≥99% deuterated forms (d1-d3); ≤1% d0

Formula Markup: C20[13C]H22D3NO • CH3SO3H

Formula Weight: 407,6

Shelf life (days): 1460

Notes: Benztropine-13C-d3 is intended for use as an internal standard for the quantification of benztropine (Item No. 16214) by GC- or LC-MS. Benztropine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 0.59 nM in rat brain membranes).{26585} It is selective for M1 receptors over the serotonin transporter (Ki = 5,150 nM), however, it also binds to the dopamine transporter and inhibits dopamine reuptake (Kis = 237 and 130 nM, respectively).{26585,20213,26584} Benztropine also inhibits acid sphingomyelinase by 87% when used at a concentration of 10 mM.{26583} Formulations containing benztropine have been used in the management of Parkinson's disease symptoms such as involuntary tremor and dystonia.

• Artikelnummer: CAY29644
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29644-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung