Bethanechol-d6 (chloride)

Formulation: A solid

Formal Name: 2-[(aminocarbonyl)oxy]-N-methyl-N,N-di(methyl-d3)-1-propanaminium, monochloride

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C7H11D6N2O2 • Cl

Formula Weight: 202,7

Shelf life (days): 1460

Notes: Bethanechol-d6 is intended for use as an internal standard for the quantification of bethanechol (Item No. 23830) by GC- or LC-MS. Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 µM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors.{40682} It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol (Item No. 15592) in isolated guinea pig small intestine (IC50 = 127 µM).{18340} Bethanechol increases basal tone of isolated porcine intravesical ureter (EC50 = 4.27 µM).{27105} It also induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats when administered at a dose of 60 µg/kg.{40787} Formulations containing bethanechol have been used to increase urination and improve smooth muscle tone in the gastrointestinal tract.

• Artikelnummer: CAY33299-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33299-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung