Bevantolol (hydrochloride), CAS 42864-78-8

Formulation: A crystalline solid

Formal Name: 1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol, monohydrochloride

Purity: ≥98%

Formula Markup: C20H27NO4 • HCl

Formula Weight: 381,9

Shelf life (days): 1460

CAS Number: 42864-78-8

Notes: Bevantolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 14.79 nM in rat cortical membranes).{52361} It is selective for β1- over β2-ARs (Ki = 588.84 nM), as well as α2-ARs up to 100 μM, but is an antagonist of α1-ARs (Ki = 125.89 nM). Bevantolol inhibits low voltage-activated calcium currents (LVA-ICa) in dissociated rat ventro-medial hypothalamic neurons (IC50 = 40 μM).{52362} It inhibits norepinephrine-induced contraction of isolated rabbit thoracic aorta (pA2 = 4.77), isoprenaline-induced inotropic effects in isolated guinea pig right atria (pA2 = 7.74), and isoprenaline-induced relaxation of isolated guinea pig trachea (pA2 = 6.69).{52363} Bevantolol (250 mg/kg per day) prevents immobilization stress-induced increases in systolic blood pressure in a rat model of stress-induced hypertension.{52364}

• Artikelnummer: CAY29792-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29792-250
• Green Labware: Nein
• Verpackungseinheit: 250 mg
• Mengeneinheit: STK