Bexarotene-d4, CAS 2182068-00-2

Formulation: A crystalline solid

Formal Name: 4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]-benzoic acid-d4

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C24H24D4O2

Formula Weight: 352,5

Shelf life (days): 1460

CAS Number: 2182068-00-2

Notes: Bexarotene-d4 is intended for use as an internal standard for the quantification of bexarotene (Item No. 11571) by GC- or LC-MS. Bexarotene is a high-affinity ligand for retinoid X receptors (RXRs) (EC50s = 28, 25, and 20 nM for RXRα, β, and γ, respectively).{20758} It inhibits cell cycle progression, induces apoptosis, prevents or overcomes multidrug resistance through multidrug resistance protein 1 (MDR1), and blocks angiogenesis and metastasis, making it a promising chemopreventive agent against cancer.{20757,20760} Bexarotene also, through RXR activation, stimulates clearance of soluble β-amyloid, reduces plaque area, and reverses deficits related to Alzheimer’s disease in mice.{20759}

• Artikelnummer: CAY22610
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22610-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung