Formulation: A crystalline solid
Formal Name: 4,6-bis(dimethylamino)-2-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methyl]-5-pyrimidineacetic acid
Purity: ≥98%
Formula Markup: C25H26F3N5O3
Formula Weight: 501,5
Shelf life (days): 1460
CAS Number: 1093108-50-9
Notes: BI-671800 is an antagonist of the prostaglandin D2 (PGD2; Item No. 12010) receptor CRTH2/DP2 (IC50 = 42 nM in a radioligand binding assay).{17373} It binds selectively to CRTH2/DP2 over DP1, thromboxane, and prostacyclin receptors (IC50s = 25.6, 62.6, and >100 μM, respectively). BI-671800 inhibits PGD2-induced shape change in human eosinophils (IC50 = 744 nM).