BIBS39, CAS 133085-33-3

Formulation: A crystalline solid

Formal Name: 4'-[[2-butyl-6-[[(cyclohexylamino)carbonyl]amino]-1H-benzimidazol-1-yl]methyl]-[1,1'-biphenyl]-2-carboxylic acid

Purity: ≥98%

Formula Markup: C32H36N4O3

Formula Weight: 524,7

Shelf life (days): 1460

CAS Number: 133085-33-3

Notes: BIBS39 is a nonpeptide antagonist of the angiotensin II type 1 (AT1) receptor (Ki = 29 nM in rat lung membranes).{46447} It is selective for AT1 over AT2 receptors (Ki = 480 nM in isolated rat adrenal medulla), as well as α1-, α2-, β1-, and β2-adrenergic, adenosine A1 and A2, muscarinic M1, M2, and M3, and atrial natriuretic peptide receptors (Kis = >100 µM for all). BIBS39 (0.3-10 mg/kg) decreases diastolic blood pressure in pithed normotensive rats without affecting heart rate and in renal hypertensive rats with an increase in heart rate when administered at doses ranging from 1 to 30 mg/kg.{46447,46448}

• Artikelnummer: CAY22932-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22932-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK