Biperiden-d5, CAS 2938691-75-7

Formulation: A solid

Formal Name: α-bicyclo[2.2.1]hept-5-en-2-yl-(α-phenyl-d5)-1-piperidinepropanol

Purity: ≥99% deuterated forms (d1-d5)

Formula Markup: C21H24D5NO

Formula Weight: 316,5

Shelf life (days): 1460

CAS Number: 2938691-75-7

Notes: Biperiden-d5 is intended for use as an internal standard for the quantification of biperiden by GC- or LC-MS. Biperiden is an antagonist of muscarinic acetylcholine receptors (mAChRs; IC50s = 0.48, 6.3, 3.9, 2.4, and 6.3 nM for M1-5 receptors, respectively).{22786} It increases spontaneous and electrically evoked dopamine release and electrically evoked acetylcholine (ACh) release from rabbit caudate nucleus slices preincubated with dopamine.{39395} Biperiden (10 µM) also inhibits NMDA-induced ACh release in rabbit caudate nucleus slices.{39396} Biperiden (0.01-1.0 mg/kg) reduces physostigmine-induced tremor in rats.{39397} Formulations containing biperiden have been used as an adjuvant treatment for Parkinson's disease.

• Artikelnummer: CAY33469-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33469-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung