Bisoprolol (hemifumarate), CAS 104344-23-2

Formulation: A crystalline solid

Formal Name: 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol, (2E)-2-butenedioate (2:1)

Purity: ≥98%

Formula Markup: C18H31NO4 • 1/2C4H4O4

Formula Weight: 325,4

Shelf life (days): 1460

CAS Number: 104344-23-2

Notes: Bisoprolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 25 nM for the human receptor).{39505} It is selective for β1- over β2-ARs (Ki = 480 nM for the human receptor in a radioligand binding assay).{39505} Bisoprolol binds to rat ventricular myocytes and heart membranes that endogenously express β1-ARs and β1- and β2-ARs, respectively (Kis = 20 and 38.1 nM, respectively).{39507} In vivo, bisoprolol (0.3 mg/kg) inhibits increases in heart rate and myocardial contractility induced by isoproterenol (Item No. 15592) in conscious dogs.{39509} It decreases blood pressure and heart rate in spontaneously hypertensive rats (SHRs) when chronically administered at a dose of 7.5 mg/kg twice per day over 19 weeks. Bisoprolol also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro; IC50 = 118.5 µg/ml) and reduces viral infectivity in SARS-CoV-2 infected Vero E6 cells (IC50 = 15.917 µg/ml).{64706} Formulations containing bisoprolol have been used in the treatment of heart failure, angina pectoris, mild to moderate hypertension, and for secondary prevention of myocardial infarction.

• Artikelnummer: CAY23827-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23827-250
• Green Labware: Nein
• Verpackungseinheit: 250 mg
• Mengeneinheit: STK