BKT 140, CAS 664334-36-5

Formulation: A crystalline solid

Formal Name: N2-(4-fluorobenzoyl)-L-arginyl-L-arginyl-3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-N5-(aminocarbonyl)-L-ornithyl-L-lysyl-D-lysyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl-L-argininamide, cyclic (4→13)-disulfide

Purity: ≥95%

Formula Markup: C97H144FN33O19S2

Formula Weight: 2159,5

Shelf life (days): 1460

CAS Number: 664334-36-5

Notes: BKT 140 is an antagonist of chemokine (C-X-C motif) receptor 4 (CXCR4; IC50 = 0.91 nM).{54472} It inhibits HIV-1-induced cytopathogenicity in MT-4 cells with an EC50 value of 4 nM. BKT 140 (100 nM) reduces migration of SUP-T1 leukemia and MDA-MB-231 breast cancer cells induced by chemokine (C-X-C) ligand 12 (CXCL12).{54472} It induces apoptosis in NB4 leukemia and RPMI-8226 multiple myeloma cancer cells when used at concentrations 8 and 40 µM.{54473} BKT 140 reduces pulmonary metastasis in an MDA-MB-231 mouse xenograft model.{54472} It also reduces the incidence of arthritis in a mouse model of collagen-induced arthritis.{54474}

• Artikelnummer: CAY30689-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30689-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK