BMS 779788, CAS 918348-67-1

Formulation: A crystalline solid

Formal Name: 2-[1-(2-chlorophenyl)-1-methylethyl]-α,α-dimethyl-1-[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-1H-imidazole-4-methanol

Purity: ≥98%

Formula Markup: C28H29ClN2O3S

Formula Weight: 509,1

Shelf life (days): 1460

CAS Number: 918348-67-1

Notes: BMS 779788 is a partial agonist of liver X receptor α (LXRα) and LXRβ (Kis = 68 and 14 nM, respectively, in a radioligand binding assay).{45493} It activates LXRα and LXRβ with EC50 values of 230 and 250 nM, respectively, in a transactivation assay. BMS 779788 increases expression of ATP-binding cassette transporter (ABCA1) in HeLa cells and isolated human and mouse whole blood (EC50s = 33, 1,200, and 120 nM, respectively). It also increases expression of Abca1 and Abcg2 in isolated mouse blood cells but does not increase plasma or hepatic triglycerides when administered at a dose of 10 mg/kg.

• Artikelnummer: CAY27339-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27339-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK