BMS 813160, CAS 1286279-29-5

Formulation: A crystalline solid

Formal Name: N-[(1R,2S,5R)-5-[(1,1-dimethylethyl)amino]-2-[(3S)-3-[[7-(1,1-dimethylethyl)pyrazolo[1,5-a]-1,3,5-triazin-4-yl]amino]-2-oxo-1-pyrrolidinyl]cyclohexyl]-acetamide

Purity: ≥98%

Formula Markup: C25H40N8O2

Formula Weight: 484,6

Shelf life (days): 1460

CAS Number: 1286279-29-5

Notes: BMS 813160 is a dual antagonist of chemokine receptor 2 (CCR2) and CCR5 (IC50s = 6.2 and 3.6 nM, respectively, in radioligand binding assays).{46418,46419} It inhibits chemotaxis induced by the CCR2 ligand MCP-1 in THP-1 cells the CCR5 ligand MIP-1β in isolated peripheral T cells with IC50 values of 0.8 and 1.1 nM, respectively.{46418} BMS 813160 inhibits peritoneal monocyte and macrophage infiltration in an hCCR-2 KI mouse model of thioglycolate-induced peritonitis, with 54% inhibition when administered at a dose of 50 mg/kg twice per day.

• Artikelnummer: CAY28421-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28421-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK