BMS 986120, CAS 1478712-37-6

Formulation: A crystalline solid

Formal Name: 2-methoxy-6-[6-methoxy-4-[[5-methyl-2-(4-morpholinyl)-4-thiazolyl]methoxy]-2-benzofuranyl]-imidazo[2,1-b]-1,3,4-thiadiazole

Purity: ≥98%

Formula Markup: C23H23N5O5S2

Formula Weight: 513,6

Shelf life (days): 1460

CAS Number: 1478712-37-6

Notes: BMS 986120 is an orally bioavailable, selective, and reversible antagonist of proteinase-activated receptor 4 (PAR4; IC50 = 0.56 nM to inhibit calcium mobilization induced by PAR4 agonist peptide (PAR4-AP) in HEK293 cells).{36234} It is selective for PAR4 over PAR1, PAR2, and a panel of purified proteases, including thrombin. It inhibits platelet aggregation in vitro in human platelet-rich plasma (IC50 = 7.3 nM). BMS 986120 (0.2-1 mg/kg) decreases platelet aggregation induced by PAR4-AP ex vivo in a dose-dependent manner, but does not increase clotting times. In vivo, BMS 986120 (1 mg/kg) prevents vascular occlusion and reduces thrombus formation by 82% in cynomolgus monkeys.

• Artikelnummer: CAY23497-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23497-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK