BMS 986122, CAS 313669-88-4

Formulation: A crystalline solid

Formal Name: 2-(3-bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine

Purity: ≥98%

Formula Markup: C16H15BrClNO3S2

Formula Weight: 448,8

Shelf life (days): 1460

CAS Number: 313669-88-4

Notes: BMS 986122 is a positive allosteric modulator of μ-opioid receptors that increases β-arrestin recruitment stimulated by endomorphin 1 (Item No. 23280) in U2OS-OPRM1 human osteosarcoma cells expressing μ-opioid receptors (EC50 = 3 μM).{37687} It potentiates endomorphin 1-induced inhibition of forskolin-stimulated adenylyl cyclase activity in CHO cells expressing human recombinant μ-opioid receptors (EC50 = 8.9 μM). BMS 986122 also enhances [35S]GTPγ binding stimulated by the μ-opioid agonist DAMGO (Item No. 21553) by 7- and 4.5-fold in C6μ glioma cell membranes that express μ-opioid receptors and mouse brain membranes, respectively.

• Artikelnummer: CAY23269-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23269-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK