BP-897, CAS 314776-92-6

Formulation: A crystalline solid

Formal Name: N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-2-naphthalenecarboxamide, monohydrochloride

Purity: ≥98%

Formula Markup: C26H31N3O2 • HCl

Formula Weight: 454

Shelf life (days): 1460

CAS Number: 314776-92-6

Notes: BP-897 is a dopamine D3 receptor partial agonist.{47754} It selectively binds to the dopamine D3 over the D2, D1, and D4 receptors (Kis = 0.92, 61, 3,000, and 300 nM, respectively, for the recombinant human receptors). It is also selective over α1- and α2-adrenergic receptors (Kis = 60 and 83 nM, respectively) and the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT7 (Kis = 84 and 345 nM, respectively), as well as muscarinic, histamine, and opioid receptors (Kis = >1 µM for all). BP-897 inhibits cAMP accumulation induced by forskolin (EC50 = 1 nM) and increases mitogenesis in NG 108-15 cells with a maximum efficacy of 55%, an effect that can be blocked by the dopamine D3 receptor antagonist nafadotride. It also acts as a dopamine D3 receptor antagonist, failing to increase [35S]GTPγS binding to CHO cell membranes expressing the recombinant human D3 receptor and inhibiting the effect of dopamine in the same assay (IC50 = 416.87 nM).{47755} BP-897 (0.5 and 1 mg/kg) reduces cocaine-seeking behavior, but has no reinforcing properties itself, in rats trained to self-administer cocaine.{47754}

• Artikelnummer: CAY25831-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25831-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK