BPTU, CAS 870544-59-5

Formulation: A solid

Formal Name: N-[2-[2-(1,1-dimethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoromethoxy)phenyl]-urea

Purity: ≥98%

Formula Markup: C23H22F3N3O3

Formula Weight: 445,4

Shelf life (days): 1460

CAS Number: 870544-59-5

Notes: BPTU is an allosteric antagonist of the purinergic P2Y1 receptor (Ki = 6 nM for the human receptor).{53133,53134} BPTU is selective for P2Y1 over P2Y2, P2Y6, P2Y11, P2Y12, and P2Y14 receptors (Kis = ≥3,500 nM).{53133} It inhibits platelet aggregation in human platelet-rich plasma (hPRP; IC50 = 2.1 µM). BPTU reduces thrombus weight by 68% in a rat model of iron chloride-induced arterial thrombosis and prolongs provoked cuticle and mesenteric bleeding time in rats when administered intravenously as a 10 mg/kg bolus dose followed by a 10 mg/kg per hour infusion. It also inhibits contractions induced by electrical field stimulation in isolated muscle strips from rat and mouse colon (EC50s = 0.5 and 0.1 µM, respectively) and antrum (EC50s = 9 and 0.3 µM, respectively).{53134}

• Artikelnummer: CAY29444-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29444-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK