Brexpiprazole, CAS 913611-97-9

Formulation: A crystalline solid

Formal Name: 7-[4-(4-benzo[b]thien-4-yl-1-piperazinyl)butoxy]-2(1H)-quinolinone

Purity: ≥98%

Formula Markup: C25H27N3O2S

Formula Weight: 433,6

Shelf life (days): 1460

CAS Number: 913611-97-9

Notes: Brexpiprazole is a serotonin (5-HT) and dopamine receptor modulator that has high affinity (Ki = 1A and 5-HT2A serotonin, dopamine D2L, and α1B-, and α2C-adrenergic receptors in CHO cell membranes expressing the human receptors.{39167} It acts as a partial agonist of 5-HT1A, D2L, and D3 receptors (EC50s = 0.49, 4.0, and 2.8 nM, respectively) and an antagonist of 5-HT2A, 5-HT2B, as well as α1B- and α2C-adrenergic receptors (IC50s = 6.5, 14, 0.66, and 63 nM, respectively) in vitro. In vivo, brexpiprazole dose-dependently reduces conditioned avoidance response (CAR) time, inhibits locomoter hyperactivity induced by apomorphine (Item No. 16094) and amphetamine, and reverses cognitive defects induced by subchronic PCP administration in rats.{39168} It also reduces apomorphine-induced eye blinking in cynomolgus monkeys. Formulations containing brexpiprazole have been used in the treatment of schizophrenia and major depressive disorder.

• Artikelnummer: CAY22906-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22906-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK