BSP-16, CAS 2727249-47-8

Formulation: A solid

Formal Name: αR-ethyl-5,6-dimethoxy-γ-oxo-benzo[b]selenophene-2-butanoic acid

Purity: ≥98%

Formula Markup: C16H18O5Se

Formula Weight: 369,3

Shelf life (days): 1095

CAS Number: 2727249-47-8

Notes: BSP-16 is a stimulator of interferon genes (STING) agonist.{66413} It binds to STING (Kd = 23 µM) and induces the production of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells when used at concentrations of 10, 25, and 50 µM. BSP-16 (50 µM) induces phosphorylation of IFN regulatory factor 3 (IRF3) and TANK-binding kinase 1 (TBK1) in THP-1 cells. In vivo, BSP-16 (15 and 30 mg/kg) reduces tumor volume in an MC-38 murine carcinoma model and induces tumor regression in a CT26 murine colorectal carcinoma model. It prevents tumor cell re-challenge-induced tumor formation in a CT26 murine carcinoma model. BSP-16 (20 mg/kg) also reduces tumor volume and increases the number of activated CD8+ T cells and natural killer (NK) cells in a 4T1 murine mammary carcinoma model.

• Artikelnummer: CAY37992-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37992-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe