Buflomedil (hydrochloride), CAS 35543-24-9

Formulation: A solid

Formal Name: 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone, monohydrochloride

Purity: ≥95%

Formula Markup: C17H25NO4 • HCl

Formula Weight: 343,9

Shelf life (days): 1460

CAS Number: 35543-24-9

Notes: Buflomedil is a non-selective antagonist of α-adrenergic receptors (α-ARs) and vasoactive compound.{58021,58022,58023,58024} It binds to rat α1A- and α1B-ARs (Kis = 4.06 and 6.84 µM, respectively) and human platelet α2-ARs (IC50 = 1 µM) in radioligand binding assays.{58021,58022} Buflomedil (0.06-60 µM) inhibits contraction of isolated canine saphenous veins induced by phenylephrine, clonidine (Item No. 15949), sympathetic nerve stimulation, or norepinephrine.{58023} It inhibits ADP-, collagen-, or epinephrine-induced aggregation of isolated human platelets when used at a concentration of 100 µM.{58022} Buflomedil (10 mg/kg) reduces hippocampal neuronal cell death in a rat model of carotid clamping-induced ischemia-reperfusion injury.{58024}

• Artikelnummer: CAY31184-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31184-10
• Green Labware: Nein
• Verpackungseinheit: 10 g
• Mengeneinheit: STK