C-DIM5, CAS 33985-68-1

Formulation: A solid

Formal Name: 3,3'-[(4-methoxyphenyl)methylene]bis-1H-indole

Purity: ≥98%

Formula Markup: C24H20N2O

Formula Weight: 352,4

Shelf life (days): 1460

CAS Number: 33985-68-1

Notes: C-DIM5 is a para-phenyl-substituted diindolylmethane (C-DIM) and an agonist of the orphan receptor nuclear receptor-related protein 77 (Nur77).{49136} It selectively activates Nur77 over peroxisome proliferator receptor γ (PPARγ) in reporter assays when used at a concentration of 20 μM. C-DIM5 (10, 15, and 20 μM) inhibits growth of and induces apoptosis in L3.6pL pancreatic cancer cells.{49137} It stabilizes nuclear localization of Nur77 and Nurr1 and reduces secretion of the pro-inflammatory cytokines IL-2, IL-6, IL-12p70, CCL2, and CCL5 in primary mouse astrocytes.{49138} Oral administration of C-DIM5 (50 mg/kg) prevents loss of dopaminergic neurons in the substantia nigra pars compacta and striatal dopamine terminals in a mouse model of Parkinson's disease induced by MPTP.{49139}

• Artikelnummer: CAY27980-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27980-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK