C3001a, CAS 2415154-29-7

Formulation: A crystalline solid

Formal Name: (1S,3R)-3-[[[4-(6-methyl-2-benzothiazolyl)phenyl]amino]carbonyl]-cyclopentanecarboxylic acid

Purity: ≥98%

Formula Markup: C21H20N2O3S

Formula Weight: 380,5

Shelf life (days): 730

CAS Number: 2415154-29-7

Notes: C3001a is an activator of the two-pore domain potassium channels K2P2.1/TREK1 and K2P10.1/TREK2.{59302} It increases current amplitude in HEK293T cells expressing K2P2.1/TREK1 or K2P10.1/TREK2 (EC50s = 12.81 and 11.31 µM, respectively, for the human channels). C3001a is selective for K2P2.1/TREK1 and K2P10.1/TREK2 over a panel of five additional K2P channels at 10 µM. In vivo, C3001a (10 mg/kg) reduces edema and pancreatic necrosis in a mouse model of acute pancreatitis. It reduces mechanical and thermal hyperalgesia in a mouse model of chronic inflammatory pain induced by complete Freund's adjuvant (CFA). C3001a (5 mg/kg) also reduces cold hyperalgesia in a mouse model of neuropathic pain induced by spared nerve injury (SNI).

• Artikelnummer: CAY31064-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31064-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK