Calcitonin (salmon) (trifluoroacetate salt), CAS 171052-37-2

Formulation: A lyophilized powder

Formal Name: L-cysteinyl-L-seryl-L-asparaginyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucylglycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-α-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-Lthreonyl-L-asparaginyl-L-threonylglycyl-L-serylglycyl-L-threonyl-L-prolinamide, cyclic (1→7)-disulfide, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C145H240N44O48S2 • XCF3COOH

Formula Weight: 3431,9

Shelf life (days): 1460

CAS Number: 171052-37-2

Notes: Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption.{38632,39431} It belongs to the calcitonin family of peptides, which also includes amylin (Item No. 24274), calcitonin gene-related peptide (Item No. 24405), and adrenomedullin.{38633} The binding of salmon calcitonin to the human calcitonin receptor (CTR) is not modulated by receptor activity-modifying proteins (RAMPs), which influence affinity of human calcitonin (Item No. 24409) to CTR.{38634,39432} Salmon calcitonin binds to human CTR2 with IC50 values of 0.933, 0.224, 0.134, and 0.317 nM alone and with RAMP1, 2, or 3, respectively. It induces cAMP accumulation in COS-7 cells transfected with CTR2 (EC50 = 0.166 nM).{39433} Salmon calcitonin inhibits bone resorption by osteoclasts in a pit formation assay using rat bone slices (ID50 = 0.003 pg/mL) and lowers calcium level in vivo in a bioassay of hypocalcemia in rats (ED15 = 33.9 mg/kg).{39434} Formulations containing salmon calcitonin have been used to treat hypercalcemia, bone destruction by osteoporosis, and Paget's disease.{39431}

• Artikelnummer: CAY24410
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24410-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK